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Description
AP2α Recombinant Rabbit mAb (S-2376-7)Product Specification Host Rabbit Antigen AP2 Synonyms Transcription factor AP 2 alpha; AP2 alpha; AP 2 transcription factor; Activating enhancer binding protein 2 alpha; Activator protein 2 (AP 2); AP2TF; TFAP2; TFAP2A Immunogen Synthetic Peptide Location Nucleus Accession P05549 Clone Number S 2376 7 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample SK BR 3, T 47D, HeLa, 293T Purification
Product Specification
| Host | Rabbit |
| Antigen | AP2α |
| Synonyms | Transcription factor AP-2-alpha; AP2-alpha; AP-2 transcription factor; Activating enhancer-binding protein 2-alpha; Activator protein 2 (AP-2); AP2TF; TFAP2; TFAP2A |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | P05549 |
| Clone Number | S-2376-7 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | SK-BR-3, T-47D, HeLa, 293T |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:250 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
Background
AP2α (Activating Protein-2α) is a nuclear transcription factor belonging to the AP-2 family, which specifically binds to DNA and regulates gene expression. It plays a critical role in various biological processes, including embryonic development, cell proliferation, apoptosis, tumor suppression, and immune regulation. The AP2α protein structure consists of an N-terminal proline- and glutamine-rich (P/Q-rich) transactivation domain, a central basic region, and a highly conserved C-terminal helix-span-helix motif responsible for DNA binding and protein dimerization. Studies have shown that AP2α acts as a tumor suppressor in multiple cancers (e.g., gastric, colorectal, and liver cancers) by regulating downstream target genes (such as p21, caspase family members, and EGF receptor) to inhibit tumor cell proliferation and promote apoptosis. Additionally, AP2α is involved in metabolic regulation (e.g., lipid synthesis) and inflammatory responses. For instance, in atherosclerosis, it upregulates IkBα expression via the AMPK signaling pathway to suppress vascular inflammation. In immunity, AP2α has been found to be significantly upregulated (particularly in the liver) in yellow croaker (Larimichthys crocea) in response to Vibrio harveyi infection, indicating its role in innate immune defense. Dysregulated expression or dysfunction of AP2α is associated with various diseases, making it a potential diagnostic biomarker and therapeutic target.
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