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Description
MFG1-E8 Recombinant Rabbit mAb (S-2530-74)Product Specification Host Rabbit Antigen MFG1 E8 Synonyms Lactadherin; Breast epithelial antigen BA46; HMFG; MFGM; Milk fat globule EGF factor 8 (MFG E8); SED1; MFGE8 Immunogen Synthetic Peptide Location Secreted Accession Q08431 Clone Number S 2530 74 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu Positive Sample A549, PANC 1, human milk Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated
Product Specification
| Host | Rabbit |
| Antigen | MFG1-E8 |
| Synonyms | Lactadherin; Breast epithelial antigen BA46; HMFG; MFGM; Milk fat globule-EGF factor 8 (MFG-E8); SED1; MFGE8 |
| Immunogen | Synthetic Peptide |
| Location | Secreted |
| Accession | Q08431 |
| Clone Number | S-2530-74 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu |
| Positive Sample | A549, PANC-1, human milk |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Hu |
| IHC-P | 1:1000 | Hu |
| ICC | 1:500 | Hu |
Background
Milk fat globule-EGF factor 8 (MFG-E8), also called lactadherin, is a secreted 66–75 kDa glycoprotein composed of an N-terminal EGF-like domain containing an RGD integrin-binding motif and two C-terminal discoidin/F5-8 domains that bind phosphatidylserine, enabling it to act as a bridging molecule between apoptotic cells and phagocytes expressing αvβ3/αvβ5 integrins, thereby orchestrating efferocytosis, dampening inflammation, and exerting pleiotropic effects on vascular remodeling, skeletal-muscle lipid metabolism, myogenic differentiation, osteoclastogenesis, and tumor progression while also giving rise to the amyloidogenic peptide medin found in aged arterial walls.
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Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
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