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Description
14-3-3 sigma Recombinant Rabbit mAb (S-2017-59)Product Specification Host Rabbit Antigen 14 3 3 sigma Synonyms 14 3 3 protein sigma; Epithelial cell marker protein 1; Stratifin; HME1; SFN Immunogen Synthetic Peptide Location Secreted, Cytoplasm, Nucleus Accession P31947 Clone Number S 2017 59 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms Positive Sample HeLa, A431, MCF7, Mouse colon Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated
Product Specification
| Host | Rabbit |
| Antigen | 14-3-3 sigma |
| Synonyms | 14-3-3 protein sigma; Epithelial cell marker protein 1; Stratifin; HME1; SFN |
| Immunogen | Synthetic Peptide |
| Location | Secreted, Cytoplasm, Nucleus |
| Accession | P31947 |
| Clone Number | S-2017-59 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms |
| Positive Sample | HeLa, A431, MCF7, Mouse colon |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu, Ms |
| IHC-P | 1:2000 | Hu |
| ICC | 1:500 | Hu |
Background
The 14-3-3 sigma protein, also known as stratifin, is a member of the 14-3-3 protein family that plays a crucial role in cell cycle regulation. It functions primarily to inhibit the progression of cells from the G2 phase to the M phase by preventing the activation of cyclin-dependent kinases. This protein is highly expressed in various tissues and is involved in maintaining genomic stability. Additionally, 14-3-3 sigma has been implicated in several cellular processes, including apoptosis and signal transduction pathways. Dysregulation of 14-3-3 sigma has been associated with certain cancers and other diseases, making it a potential target for therapeutic interventions.
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