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Description
RB1CC1 Recombinant Rabbit mAb (S-2367-251)Product Specification Host Rabbit Antigen RB1CC1 Synonyms RB1 inducible coiled coil protein 1; FAK family kinase interacting protein of 200 kDa (FIP200); KIAA0203; RBICC Immunogen Synthetic Peptide Location Cytoplasm, Nucleus, Lysosome Accession Q8TDY2 Clone Number S 2367 251 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample A172, Jurkat, A20, mouse testis Purification Protein A Concentration 2
Product Specification
| Host | Rabbit |
| Antigen | RB1CC1 |
| Synonyms | RB1-inducible coiled-coil protein 1; FAK family kinase-interacting protein of 200 kDa (FIP200); KIAA0203; RBICC |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus, Lysosome |
| Accession | Q8TDY2 |
| Clone Number | S-2367-251 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | A172, Jurkat, A20, mouse testis |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
| IHC-P | 1:200 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
Background
RB1CC1 (also known as FIP200) is a multifunctional 183-kDa scaffolding protein that nucleates the ULK1-ATG13-RB1CC1-ATG101 complex to initiate autophagosome formation in response to nutrient or mTOR signals, acts in the nucleus as a GC-rich DNA-binding transcription factor that up-regulates RB1, p16 and p21 to enforce cell-cycle checkpoints, and simultaneously controls migration, differentiation and survival by inhibiting the focal-adhesion kinases PTK2/FAK1 and PTK2B/PYK2 and by modulating TSC1, p53 and TGF-β pathways, thereby operating as a central tumor-suppressor whose loss or mis-localation is linked to aggressive breast, prostate and pancreatic cancers as well as to fibrotic and neuro-developmental disorders.
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