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Description
IL1RL1/ST2 (isoform A) His Tag Protein, HumanProduct Specification Species Human Synonyms IL1RL1, DER4, FIT 1, IL33R, ST2, ST2L, ST2V, T1 Accession Q01638 Amino Acid Sequence Lys19 Ser328, with C terminal 8*His
Product Specification
| Species | Human |
| Synonyms | IL1RL1, DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1 |
| Accession | Q01638 |
| Amino Acid Sequence | Lys19-Ser328, with C-terminal 8*His KFSKQSWGLENEALIVRCPRQGKPSYTVDWYYSQTNKSIPTQERNRVFASGQLLKFLPAAVADSGIYTCIVRSPTFNRTGYANVTIYKKQSDCNVPDYLMYSTVSGSEKNSKIYCPTIDLYNWTAPLEWFKNCQALQGSRYRAHKSFLVIDNVMTEDAGDYTCKFIHNENGANYSVTATRSFTVKDEQGFSLFPVIGAPAQNEIKEVEIGKNANLTCSACFGKGTQFLAAVLWQLNGTKITDFGEPRIQQEEGQNQSFSNGLACLDMVLRIADVKEEDLLLQYDCLALNLHGLRRHTVRLSRKNPIDHHSGGGSHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 55-72kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Savenije O E. et al. (2011) Interleukin-1 receptor-like 1 polymorphisms are associated with serum IL1RL1-a, eosinophils, and asthma in childhood. J Allergy Clin Immunol. 127(3): 750-756. 2、Li H. et al. (2000) The cloning and nucleotide sequence of human ST2L cDNA. Genomics. 67(3): 284-290. |
Background
ST2, also known as IL-1 R4 and T1, is an Interleukin-1 receptor family glycoprotein that contributes to Th2 immune responses. Human ST2 consists of a 310 amino acid (aa) extracellular domain (ECD) with three Ig-like domains, a 21 aa transmembrane segment, and a 207 aa cytoplasmic domain with an intracellular TIR domain. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiac myocytes. It binds IL-33, a cytokine that is upregulated by inflammation or mechanical strain in smooth muscle cells, airway epithelia, keratinocytes, and cardiac fibroblasts. IL-33 binding induces the association of ST2 with IL-1R AcP, a shared signaling subunit that also associates with IL-1 RI and IL-1 R rp2. In macrophages, ST2 interferes with signaling from IL-1 RI and TLR4 by sequestering the adaptor proteins MyD88 and Mal. In addition to its role in promoting mast cell and Th2 dependent inflammation, ST2 activation enhances antigen induced hypernociception and protects from atherosclerosis and cardiac hypertrophy. Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages.
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4.9 ★★★★★
Based on 8 reviews
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Product Reviews
★★★★★ 4
Slightly challenging build
Color: Beige, Size: A-88''W-4 Panel
This was my second screen set I've purchased, first of this style. Not the easiest to assemble. Lots of pulling and tugging; not a highlight in my day.
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Reviewed in the United States on January 15, 2026
★★★★★ 5
Commercial grade divider suitable for many needs
Color: Beige, Size: A-132''W-6 Panel
This item will be used at a future event where we need to separate a single locker room into two large areas, without any construction. This divider is perfect for the job because the partitions can be 1 to 6 panels and it will roll into place. When the event is over, the divider will fold/roll away and the locker room will return to its original design.
The unit is very heavy, which will ensure that it is sturdy and stable. All the components arrived, wrapped in plastic to prevent damage. The screen material is a woven polyester in a cream color that will occlude any visibility but it may be possible to see shadows on the opposite side. The height is about 6ft, which would require a very tall person to "peep over" the divider.
I needed a quality unit for this project and the frame, screens, and mobility will meet the needs. The divider is not the same as the small decorative dividers -- it is more of a commercial grade product, yet tasteful. If you want/need a small divider as an accent piece, this is not the best choice. This item could be used in a medical office, treatment/massage room, to divide an office room into two, or block a hallway in a building.
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Reviewed in the United States on December 2, 2025
★★★★★ 2
Flimsy
Color: Grey, Size: B-88''W-4 Panel
Would not recommend
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Reviewed in the United States on April 14, 2026
★★★★★ 5
Great option for a professional looking backdrop
Color: Black, Size: B-102''-3 Panel
I decided to try these wall dividers for my home office space since it does not have a door. I wanted to have my video calls without the rest of the room in the feed to give it a more professional feel. These being on castors make them super easy to move into position and roll off to the side when not in use. They are stable, much more than the folding screens I have tried in the past. That they are connected by the middle piece and not the top/bottom of each other allows you to adjust the positioning to your needs. Overall, this did exactly what I needed and was an affordable option. I also like that they are highly portable: if you want to take them for a booth or event, the poles all disassemble into manageable lengths that easily fit in a car and take very little time to set up again. The only thing I would change is to include a bag to store them in for transportation.
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Reviewed in the United States on November 17, 2025
★★★★★ 5
Nice and strong
Color: Black, Size: Wheel-6 Panel
Nice and strong, tedious, putting together, but very good quality
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Reviewed in the United States on March 17, 2026