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Description
RON/CD136 His Tag Protein, HumanProduct Specification Species Human Synonyms RON, CD136, MSP R, MSP receptor, MSPR, MST1R Accession Q04912 Amino Acid Sequence Glu25 Leu571, with C terminal 10*His
Product Specification
| Species | Human |
| Synonyms | RON, CD136, MSP R, MSP receptor, MSPR, MST1R |
| Accession | Q04912 |
| Amino Acid Sequence | Glu25-Leu571, with C-terminal 10*His EDWQCPRTPYAASRDFDVKYVVPSFSAGGLVQAMVTYEGDRNESAVFVAIRNRLHVLGPDLKSVQSLATGPAGDPGCQTCAACGPGPHGPPGDTDTKVLVLDPALPALVSCGSSLQGRCFLHDLEPQGTAVHLAAPACLFSAHHNRPDDCPDCVASPLGTRVTVVEQGQASYFYVASSLDAAVAASFSPRSVSIRRLKADASGFAPGFVALSVLPKHLVSYSIEYVHSFHTGAFVYFLTVQPASVTDDPSALHTRLARLSATEPELGDYRELVLDCRFAPKRRRRGAPEGGQPYPVLRVAHSAPVGAQLATELSIAEGQEVLFGVFVTGKDGGPGVGPNSVVCAFPIDLLDTLIDEGVERCCESPVHPGLRRGLDFFQSPSFCPNPPGLEALSPNTSCRHFPLLVSSSFSRVDLFNGLLGPVQVTALYVTRLDNVTVAHMGTMDGRILQVELVRSLNYLLYVSNFSLGDSGQPVQRDVSRLGDHLLFASGDQVFQVPIQGPGCRHFLTCGRCLRAWHFMGCGWCGNMCGQQKECPGSWQQDHCPPKLGGGSGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 35-43&73-80kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Mallakin A. et al. (2006) Gene expression profiles of Mst1r-deficient mice during nickel-induced acute lung injury. Am J Respir Cell Mol Biol. 34(1): 15-27. 2、Welm A L. et al. (2007) The macrophage-stimulating protein pathway promotes metastasis in a mouse model for breast cancer and predicts poor prognosis in humans. Proc Natl Acad Sci U S A. 104(18): 7570-5. |
Background
RON is a receptor tyrosine kinase (RTK) of the MET receptor family that is canonically involved in mediating growth and inflammatory signaling. This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. It had been shown that MST1R/CD136 plays a critical role in Ni-induced lung injury in mice. The overexpression of MSP, MT-SP1, and MST1R was a strong independent indicator of both metastasis and death in human breast cancer patients and significantly increased the accuracy of an existing gene expression signature for poor prognosis.
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4.8 ★★★★★
Based on 8 reviews
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Product Reviews
★★★★★ 5
Keeps my dog happy
Size: Medium
This is a fun toy for our cavalier. It's pretty versatile in how you can use it, which I like because it allows me to change things up to keep my dog engaged. He's also an aggressive chewer and he hasn't destroyed it.
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Reviewed in the United States on May 7, 2026
★★★★★ 5
Good size and great bounce!
Size: Small
My 1 1/2 year old Cavapoo loves this toy. Very light weight ball that bounces off her paws when she reaches for it and then having to chase it further. Then she charges back with it for another chase when I throw it again.
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Reviewed in the United States on May 15, 2026
★★★★★ 5
THE BEST INDESTRUCTIBLE BALL
Size: Medium, Size: Medium
I bought this ball 6 months ago and feel obligated to come back all these months later to say how great it is! My Frenchie has killed every toy he’s ever had but not this ball! He absolutely loves this ball. It’s lightweight and can be used for both indoor and outdoor play and still looks brand new.
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Reviewed in the United States on November 30, 2025
★★★★★ 1
good ball, wrong color
Size: Medium
I think the hot-ee roller is a great ball! My problem is that there is no option to select a color. I thought I was getting a purple one, since that is what is shown in the picture. As usual, I failed to read that it was assorted colors. I have a peculiar little dog that will only play with the purple one. His current purple one is in tatters. You could hardly even call it a ball at this point. We have red, blue and green and they are invisible to him.
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Reviewed in the United States on May 14, 2026
★★★★★ 5
It calms down the itching
It help calm down the itching so I scratch much less !
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Reviewed in the United States on November 5, 2024