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Description
Human sFlt-1, His tagProduct Specification Species Human Synonyms Soluble fms like tyrosine kinase 1 Accession P17948 2 Amino Acid Sequence Protein sequence(P17948 2, Ser27 His687, with C 10*His)
Product Specification
| Species | Human |
| Synonyms | Soluble fms-like tyrosine kinase 1 |
| Accession | P17948-2 |
| Amino Acid Sequence |
Protein sequence(P17948-2, Ser27-His687, with C-10*His)
|
| Expression System | HEK293 |
| Molecular Weight | Theoretical: 76.4kDa Actual: 100kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage |
|
Background
Soluble fms-like tyrosine kinase-1 (sFlt-1 or sVEGFR-1) is a tyrosine kinase protein with antiangiogenic properties. A non-membrane associated splice variant of VEGF receptor 1 (Flt-1), sFlt-1 binds the angiogenic factors VEGF (vascular endothelial growth factor) and PlGF (placental growth factor), reducing blood vessel growth through reduction of free VEGF and PlGF concentrations. In humans, sFlt-1 is important in the regulation of blood vessel formation in diverse tissues, including the kidneys, cornea, and uterus. Abnormally high levels of sFlt-1 have been implicated in the pathogenesis of preeclampsia.
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4.4 ★★★★★
Based on 17 reviews
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Product Reviews
★★★★★ 5
So good!
Format: Kindle
Wings of Stars was a fantastic first book to a new series. It grabbed me in its clutches within the first chapter and kept ahold of me.
This new world of M Sinclair and RL Caulder’s is all about angels and mythical creatures. It’s full of drama from all points. From Kieran’s awful home life to keeping the stars alive and everything in between.
Kieran is our FMC and despite everything she keeps her spirit and defiance.
Keeping to their norm, there is a group of guys for our FMC but they definitely aren’t established yet, and not fully cemented yet into being a group rather than her choosing between them.
Ronan is so sweet and gives off Daddy vibes
Gabe is also sweet and wants the best of everything for Kieran and will defend her against anyone
Bastian is slightly unhinged but I loved him immediately
Steele is a jerk… just as you find redeeming qualities, he screws up again… but yet I still want him to redeem himself.
There’s another one… but if I gave his name I would be spoiling a plot twist so you will just have to find out yourself… but you’ll love him as much as I do.
This is a slow burn but the little bit of spice we do get is hot, especially with the dirty talk.
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Reviewed in the United States on February 19, 2024
★★★★★ 5
Angels and the Fallen — Breathtaking Start
Format: Kindle
This book was EVERYTHING I expected it to be and more. Leave to R.L. Caulder and M. Sinclair to give us yet another amazing book!
Kieran and her guys hooked me from the very beginning and did not let go. Found family is one of my favorite tropes and it was done so well in this book. Couple that along with an FMC trying to find her place in the world and I was practically drooling over this book. The world building, the conflict, the wyverin sidekick — it all was done so well that it felt fresh and real.
Each love interest felt real and unique in their own ways. I felt connected to each one and like they were truly different people. I love that so much in a book and these two authors never miss with their love interests.
Multi POV, Reverse harem, who did this to you, and a magical world highlighting the angels and the fallen. This book has everything and it does it so well.
Big thank you to R.L. Caulder and M. Sinclair for the arc copy! I cannot wait for book 2!
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Reviewed in the United States on February 20, 2024
★★★★★ 4
A new take 🤔
Format: Kindle
I’m not going to go into what this book is about — by now you e already read the synopsis and have an idea — but I will give a couple of insights.
Definitely a different take on angels and their fall; I like it. This is an interesting start to a new series - YES, this does end on a cliffhanger so be prepared for that. I’m eager for the next book (and hopefully the last in this series — sometimes the author(s) will switch it up depending on how the story flows for them) in this series.
I’m hoping that a certain male character redeems himself because he’s a dick that will make the meaning of mixed signals jealous lol.
You ever watch that old movie — I think it’s call Mommy Dearest? — yea, let’s switch that up to daddy. That man would make a perfect husband to mommy dearest.
I recommend this book because while these authors are well known for their cliffhangers, they are also well known for putting out good stories.
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Reviewed in the United States on February 19, 2024
★★★★★ 3
Liked it
Format: Kindle
I liked the worlds and the characters. The prophesy is confusing in that I would think, since all worlds ore on a path to destruction, the angels would want their world to be saved. I am sure there is more evil that will be revealed as the series proceeds. I dislike a prolonged “poor little me” trope and the main character has moved past that, thankfully, and began to show a fierce attitude as the novel progressed. The last portion of the novel had some great action. It’s worth reading, just be patient with a slow start.
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Reviewed in the United States on February 14, 2024
★★★★★ 5
Monstrously Sweet
Format: Kindle
This book packs an emotional punch, especially if you’ve experienced childhood trauma (particularly abuse and/or neglect). Alexandra creates these three strong protectors who love her and will do anything to make her feel happy and safe. She started out drawing them when she was a small child, and then transitioned to stories as she grew up. Lucien, Elwin, and Kylo look frightening in their monster forms, but it’s clear that they would never hurt Alexandra, and she has never felt afraid of them. They have very distinct personalities that we get to know better throughout the book. The love and devotion they have for Alexandra is sweet and unwavering.
This is a fantastic and creative story! The world-building is wonderful - it’s a shared world with M. Sinclair, and takes place at a university for supernatural beings. The additional world-building within Alexandra’s story added even more depth and intrigue. The spicy times were 🥵 and it’s more of a medium burn, but it works with the characters and I expect that it’ll pick up quite a bit in the next books.
Monsters Within has a unique way of addressing mental health issues that can come from being abused and neglected. There are some flashbacks to Alexandra’s childhood that provide some insight but they don’t go into heavy details.
I absolutely adored this book and can’t wait for more!
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Reviewed in the United States on March 21, 2022
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