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Description
TSLP Fc Chimera Protein, HumanProduct Specification Species Human Synonyms Thymic stromal lymphopoietin Accession Q969D9 1 Amino Acid Sequence Tyr29 Gln159 with hIgG1 Fc Tag at the C Terminus Expression System HEK293 Molecular Weight 40 55kDa (Reducing) Purity 95% by SDS PAGE&HPLC Conjugation Unconjugated Tag Human IgG1 Fc Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure
Product Specification
| Species | Human |
| Synonyms | Thymic stromal lymphopoietin |
| Accession | Q969D9-1 |
| Amino Acid Sequence | Tyr29-Gln159 with hIgG1 Fc Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 40-55kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE&HPLC |
| Conjugation | Unconjugated |
| Tag | Human IgG1 Fc |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Lee YS, Noh DI, Lee SJ, Jeon MH, Kim YR, Jang WJ, Lee EW. Anti-inflammatory and barrier-restoring effects of heat-killed Lactiplantibacillus plantarum postbiotics in an in vitro model of atopic dermatitis. J Appl Microbiol. 2025 Oct 16:lxaf256. |
Background
Thymic stromal lymphopoietin (TSLP) is an interleukin-7 (IL-7)-like cytokine primarily expressed by epithelial cells such as keratinocytes. The human TSLP cDNA encodes a 159-amino acid precursor protein containing a 28-amino acid signal peptide. TSLP exhibits dual core functions: on one hand, it plays a key role in initiating type 2 immune responses by acting on its most well-characterized target cells—CD11c+ dendritic cells. It promotes TH2 cell responses and directly enhances the effector functions of CD4+ TH2 cells and basophils, thereby driving the allergic inflammation associated with diseases such as atopic dermatitis and asthma. On the other hand, TSLP also contributes to maintaining immune balance, including establishing non-deletional central tolerance, maintaining a non-inflammatory intestinal environment, and limiting pro-inflammatory cytokines. Consequently, TSLP serves as a pivotal molecular link between the epithelial barrier and the immune system, involved both in host defense against helminth parasites and in the pathogenesis of various inflammatory diseases.
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