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Description
EWSR1/EWS Recombinant Rat mAb (S-R201)Product Specification Host Rat Antigen EWSR1 EWS Synonyms RNA binding protein EWS, EWS oncogene, Ewing sarcoma breakpoint region 1 protein Location Cytoplasm, Nucleus, Cell membrane Accession Q01844 Clone Number S R201 Antibody Type Rat mAb Isotype IgG1 Application WB, IHC P, ICC, ICFCM Reactivity Hu, Ms, Rt Purification Protein G Concentration 1 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0.
Product Specification
| Host | Rat |
| Antigen | EWSR1/EWS |
| Synonyms | RNA-binding protein EWS, EWS oncogene, Ewing sarcoma breakpoint region 1 protein |
| Location | Cytoplasm, Nucleus, Cell membrane |
| Accession | Q01844 |
| Clone Number | S-R201 |
| Antibody Type | Rat mAb |
| Isotype | IgG1 |
| Application | WB, IHC-P, ICC, ICFCM |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein G |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:5000 | null |
| IHC | 1:250 | null |
| ICC | 1:250 | null |
| ICFCM | 1:500 | null |
Background
Ewing’s sarcoma (EWS) is a bone cancer arising predominantly in young children. EWSR1 (Ewing Sarcoma breakpoint region 1/EWS RNA binding protein 1) gene is ubiquitously expressed in most cell types, indicating it has diverse roles in various cellular processes and organ development. Recently, several studies have shown that missense mutations of EWSR1 genes are known to be associated with central nervous system disorders such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Otherwise, EWSR1 plays epigenetic roles in gene expression, RNA processing, and cellular signal transduction. Interestingly, EWSR1 controls micro RNA (miRNA) levels via Drosha, leading to autophagy dysfunction and impaired dermal development. Ewsr1 deficiency also leads to premature senescence of blood cells and gamete cells with a high rate of apoptosis due to the abnormal meiosis [PMID: 30481590].
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