SKU: 21095137772

PTK7/CCK4 His Tag Protein, Cynomolgus

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Description

PTK7/CCK4 His Tag Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms PTK7, CCK4, Tyrosine protein kinase like 7, Protein tyrosine kinase 7, Protein tyrosine kinase 7 Accession A0A2K5VNI5 Amino Acid Sequence Ala39 Thr712, with C terminal His Expression System HEK293 Molecular Weight 90 100kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0.

Product Specification


Species Cynomolgus
Synonyms PTK7, CCK4, Tyrosine-protein kinase-like 7, Protein-tyrosine kinase 7, Protein-tyrosine kinase 7
Accession A0A2K5VNI5
Amino Acid Sequence Ala39-Thr712, with C-terminal His
Expression System HEK293
Molecular Weight 90-100kDa
Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1、Lichtig H. et al. (2019) Ptk7 proteolytic fragment proteins function during early xenopus development. Dev Biol. 453 (1): 48-55.

2、Damelin M. et al. (2017) A ptk7-targeted antibody-drug conjugate reduces tumor-initiating cells and induces sustained tumor regressions. Sci Transl Med. 9 (372): eaag2611.

3、Berger H. et al. (2017) Ptk7 faces the wnt in development and disease. Front Cell Dev Biol. 5: 31.

Background

PTK7 comprises an extracellular region with seven immunoglobulin (Ig)-like loops, a transmembrane domain, and a cytosolic region containing a defective tyrosine kinase catalytic domain. Previous studies have reported that PTK7 functions as a co-receptor in the semaphorin/plexin signaling pathway, as well as in planar cell polarity and non-canonical Wnt signaling pathways during developmental processes. Additionally, PTK7 is associated with tumorigenesis. The expression of PTK7, which is upregulated in various malignancies, is negatively correlated with disease-free survival and/or overall survival in patients with cancer. PTK7 potentiates oncogenic signaling by functioning as a co-receptor for active RPTKs, such as FGFR1. The expression of PTK7 is also upregulated in endothelial cells, especially during tube formation.
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SKU: 21095137772

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Tyrone Adair
Chelsea, US
★★★★★ 3
Great product, very poor shipping.
Very disappointed in the shipping, the wash and wax leaked all over the rest of the products inside. Have to wash the towels due to them being full of soap. Great products, adds shine and water beading slickness.
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Reviewed in the United States on September 12, 2023
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Vincent
Grantham, US
★★★★★ 5
It just works
Works as expected
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Reviewed in the United States on October 24, 2025
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Scott A. Blomme
Bozeman, US
★★★★★ 5
Make sure delivery is not with USPS
Color: 6pcs
Product is good quality. The delivery service is the issue. No one should the USPS for anything but junk. Worthless tax payers money paying for the wages of employees who don't want to work at a government business losing billions of dollars a year.
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Reviewed in the United States on May 20, 2026
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Regan Jackson
Chelsea, US
★★★★★ 5
great product
Color: 6pcs
Works great!
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Reviewed in the United States on April 28, 2026
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Viktoriia Kharalampova
Charlottesville, US
★★★★★ 5
Great quality
Color: 6pcs
Great quality. Almost like original mops.
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Reviewed in the United States on February 8, 2026

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