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Description
ACSS2 His Tag Protein, HumanProduct Specification Species Human Synonyms ACAS2, Acetyl coenzyme A synthetase Accession Q9NR19 Amino Acid Sequence Met1 Gln701 with His Tag at the N Terminus Expression System E. coli Molecular Weight 70 100kDa (Reducing) Purity 95% by SDS PAGE &HPLC Conjugation Unconjugated Tag His Tag Physical Appearance Liquid Storage Buffer 50mM Tris, 150mM NaCl, PH7. 5, 1mM DTT, 10%Glycerol Stability & Storage Stable for 12 months upon stored at 80 from the
Product Specification
| Species | Human |
| Synonyms | ACAS2, Acetyl-coenzyme A synthetase |
| Accession | Q9NR19 |
| Amino Acid Sequence | Met1-Gln701 with His Tag at the N-Terminus |
| Expression System | E.coli |
| Molecular Weight | 70-100kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE &HPLC |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Liquid |
| Storage Buffer | 50mM Tris, 150mM NaCl, PH7.5, 1mM DTT, 10%Glycerol |
| Stability & Storage | Stable for 12 months upon stored at -80℃ from the date of receipt. And avoid repeated freeze-thaws cycles. |
| Reference | 1. Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity. Oncogene, 8(10), 2879-2887. |
Background
ACSS2 (Acyl-CoA Synthetase Short-Chain Family Member 2) is a key metabolic enzyme that catalyzes the ligation of acetate to coenzyme A (CoA), generating acetyl-CoA in an ATP-dependent reaction. It is primarily localized in the cytoplasm and nucleus and plays a critical role in cellular metabolism, particularly under stress conditions such as hypoxia, nutrient deprivation, and lipid metabolism dysregulation. ACSS2 enables cells to utilize exogenous acetate as an alternative carbon source when glucose and other nutrients are scarce. The acetyl-CoA produced by ACSS2 serves dual functions: it enters de novo lipogenesis for fatty acid synthesis and provides acetyl groups for histone acetylation, thereby regulating gene expression epigenetically. Under nutrient stress, particularly amino acid deficiency, SIRT2 deacetylates ACSS2 at lysine residue K271, leading to its ubiquitination and proteasomal degradation, which suppresses lipogenesis.
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