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Description
LECT2 Recombinant Rabbit mAb (SDT-2160-51)Product Specification Host Rabbit Antigen LECT2 Synonyms Leukocyte cell derived chemotaxin 2; LECT 2; hLECT2; LECT2 Immunogen Recombinant Protein Clone Number SDT 2160 51 Antibody Type Recombinant mAb Isotype IgG Application Sandwich ELISA Reactivity Hu Cross Reactivity No cross reactivity against AFP Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4, 0. 03% Proclin 300 Stability & Storage 12 months
Product Specification
| Host | Rabbit |
| Antigen | LECT2 |
| Synonyms | Leukocyte cell-derived chemotaxin-2; LECT-2; hLECT2; LECT2 |
| Immunogen | Recombinant Protein |
| Clone Number | SDT-2160-51 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | Sandwich ELISA |
| Reactivity | Hu |
| Cross Reactivity | No cross-reactivity against AFP |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt, 2 to 8 °C as supplied |
Background
Leukocyte cell-derived chemotaxin-2 (LECT2) is a 16-kDa secreted hepatic protein belonging to the M23 peptidase family that was first identified as a neutrophil chemoattractant but is now recognized as a multifunctional regulator of immunity, metabolism and tissue remodeling: produced chiefly by hepatocytes and released into the circulation, LECT2 modulates natural killer T-cell homeostasis in the liver, promotes chondrocyte and osteoblast proliferation, orchestrates inflammatory responses by inducing adhesion molecules and pro-inflammatory cytokines in endothelial cells, serves as a hepatokine linking obesity and fatty-liver–associated insulin resistance, exerts antiviral effects via the MET proto-oncogene, and when misfolded forms amyloid fibrils that cause LECT2 amyloidosis primarily affecting kidneys and liver; its expression spans liver, neurons, epithelia and leukocytes, its structure is stabilized by zinc binding and three disulfide bonds, and its dysregulation has been implicated in non-alcoholic steatohepatitis, rheumatoid arthritis, hepatocellular carcinoma and systemic amyloidosis, making it an emerging biomarker and therapeutic target across metabolic, inflammatory and neoplastic diseases.
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